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Molecular farming and plant pharming / biopharming - Chloroplast transformation method and Chloroplast engineering patents

Issued patents are differentiated from applications in that applications are italicized.

Bogosian, G., O=Neil, J. P., Staub, J. M., US 6,218,145, April 17, 2001, Bacterial expression system based on plastid or mitochondrial promoter combinations, Monsanto, (plastids)

Carrer, H., Bock, R., EP01245149, pub Oct 2, 2002, Plastid transformation of Lycopersicon plants, Greenovation Biotech GMBH, (tomato chloroplasts)

Chaudhuri, S., WO 0121782, pub Mar 29, 2001, Enhancer elements for increased translation in plant plastids, Calgene

Chaudhuri, S., Oakes, J. V., US 6,515,206, Feb 4, 2003, Plastid transformation of Brassica, Calgene

Daniell, H. WO 99/10513, pub Mar 4,1999, Universal Chloroplast Integration and Expression Vectors, Transformed Plants and Products Thereof, Auburn Univ.

Daniell, H., US 20020137214, pub Sept 26, 2002, Marker free transgenic plants engineering the chloroplast genome without the use of antibiotic selection ,Auburn Univ.

Daniell, H., McFadden, B. A., US 5,693, 507, Dec 2, 1997, Genetic engineering of plant chloroplasts, Auburn Univ. (chloroplasts)

Daniell, H., McFadden, B. A., US 5,932,479, Aug 3, 1999, Genetic engineering of plant chloroplasts, Auburn Univ. (chloroplasts).

Daniell, H., McFadden, B. A., US 6,642,053, Nov 4, 2003, Genetic engineering of plant chloroplasts, Auburn Univ. (chloroplasts).

Eibl, C., Huang, F-C., Klaus, S., Muhlbauer, Herz, Koop, WO 02057466, pub July 25, 2002, Processes and vectors for plastid transformation of higher plants, Icon Genetics, (gene disruption and restoration of albinos)

Heifetz, P. B., US 6,362,398, Mar 26, 2002, ClpP plastid promoter sequence, Syngenta Participations, (Arabidopsis clpP gene promoter)

Heifetz, P. B., Goff, S. A., Tuttle, A. B., Griot-Wenk, M. E., WO020612A2, pub April 13, 2000, Therapeutically active proteins in plants, Novartis, (chloroplast expression).

Herz, S., Klaus, S., Eibl, C., Muhlbauer, S., Koop, H-U., Gleba, Y., WO 02055651, pub July 18, 2002, Processes and vectors for plastid transformation, Icon Genetics,

Himmel, M. E., Schaaf, D. J., Stalker, D. M., Thomas, S. R., US 6,013,860, Jan 11, 2000, Expression of enzymes involved in cellulose modification, Calgene Inc, (chloroplasts).

Kuchuk, N. V., WO0170939, pub Sept 27, 2001, Methods for transforming plant plastids and making transplastomic plants, Icon Genetics, (Plastid recombination via cell fusion)

Lebel, E., Heifertz, P., Ward, E., Uknes, S, WO98/11235, pub Mar 19, 1998, Transgenic plants expressing cellulolytic enzymes, Novartis, (chloroplasts)

Maliga, P., Allison, L. A., Hajdukiewicz, P. T., US 6,472,586, Oct 29, 2002, Nuclear-encoded transcriptional system in plastids of higher plants, Rutgers Univ.,

Maliga, P., Carrer, H., Chaudhuri, S., US 6,297,054, Oct 2, 2001, Editing-based selectable plastid marker genes, Rutgers Univ.

Maliga, P., Kuroda, H., Khan, M. S., WO 007431A1, pub Feb 17, 2000, Translation control elements for high-level protein expression in the plastids of higher plants and methods of use thereof, Rutgers Univ.

Maliga, P., Maliga, Z. S., US 5,451,513, Sept 19, 1995, Method for stably transforming plastids of multicellular plants, Rutgers Univ. (chloroplasts).

Maliga P., Maliga, Z. S., Staub, J. M., US 6,338,168, May 14, 2002, DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein. Rutgers Univ.

Maliga P., Maliga, Z. S., Staub, J. M., Zoubenko, O., Allison, L. A., Carrer, H., Kanevski, I., US 5,877,402, Mar 2, 1999, DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein. Rutgers Univ.

Maliga, P. Sikdar, S. Reddy ,S. V., US 6,376,744, April 23, 2002, Plastid Transformation in Arabidopsis thaliana, Rutgers Univ., also WO 97/32977,.

Maliga, P., Silhavy, D., Sriraman, P., US 6,624,296, Sept 23, 2003, Plastid promoters for transgene expression in the plastids of higher plants, Rutgers Univ. WO 9855595A1, pub Dec 10, 1998

McBride, K. E., Maliga, P. US 5,545,818, 8/13/96, Expression of Bacillus thuringiensis Cry Protein in Plant Plastids, Calgene, (chloroplasts)

McBride, K. E., Nehra, N., Russell, D. A., Stalker, D. M., Staub, J. M., US 6,512,162, Jan 28, 2003, Expression of eukaryotic peptides in plant plastids, Calgene

McBride, K. E., Stalker, D. M., US 5,545,817, 8/13/96, Enhanced Expression in a Plant Plastid, Calgene.(chloroplasts)

McBride, K. E., Stalker, D. M. US 5,576,198, 11/19/96, Controlled Expression of Transgenic Constructs in Plant Plastids, Calgene, (chloroplasts)

McBride, K. E., Stalker, D. M., US 5,866,421, 2/2/99, Enhanced Expression in a Plant Plastid, Calgene, (chloroplasts)

McBride, K. E., Stalker, D. M. US 5,925,806, 7/20/99, Controlled Expression of Transgenic Constructs in Plant Plastids, Calgene, (chloroplasts)

Muehlbauer. S., Herz, S., Eibl, C., Gleba, Y., Klaus, S., Koop, H. U., WO02055651, pub July 7, 2002, Processes and vectors for plastid transformation, Icon Genetics

Muehlbauer. S., Herz, S., Eibl, C., Gleba, Y., Klaus, S., Koop, H. U., WO02057466, pub Aug 8, 2002, Processes and vectors for plastid transformation, Icon Genetics

Koop, H-U., Muhlbauer, S., Klaus, S., Eibl, C., Huang, F-C., Golds, T. J., WO 03004658, pub Jan 16, 2003, Gene expression in plastids based on replicating vectors, Icon Genetics

Russell, D. A., McBride, K. E., Nehra, N., Stalker, D. M., WO 0003012, pub Jan 20, 2000, Expression of eukaryotic peptides in plant plastids, Calgene, (chloroplasts)

Staub, J. M., WO 0104331, pub Jan 18, 2001, Enhanced expression of proteins, Calgene, (green fluorescent protein enhancer)

Staub, J. M., WO 0129241, pub April 26, 2001, Methods and vectors for site-specific recombination in plant cell plastids, Calgene

Staub, J. M., Hajdukiewicz, P., McBride, K. E., Nehra, N., Schaaf, D.J., Stalker, D. M., Ye, G., US 6,492,578, Dec 10, 2002, Expression of herbicide tolerance genes in plant plastids, Calgene, (Glyphosate and all common herbicides)

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