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BIOPHARMACEUTICALS
for HUMAN HEALTH in TRANSGENIC PLANTS.
from
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TRENDS in Plant Science Vol.6
No.5 {page 224}
© - Elsevier Science 2001
The production of biopharmaceuticals
for human health in transgenic plants
Key- Potential
application or indication - Plant host
- Protein - Expression
levels - TSP = total
soluble protein.
Human proteins
Anticoagulant
Tobacco Human
protein C <0.01% TSP
Thrombin inhibitor Canola
( Brassica napus) Human hirudin
0.30% seed protein
Neutropenia Tobacco
Human granulocyte-macrophage colony-stimulating
factor Not reported
Growth hormone Tobacco
Human somatotropin, chloroplast 7.00% TSP
Growth hormone Tobacco
Nuclear expression <0.01%
TSP
Anemia Tobacco
Human erythropoietin <0.01
TSP
Antihyperanalgesic by opiate activity Arabidopsis
Human enkephalins 0.10%
seed protein
Wound repair and control of cell proliferation
Tobacco Human epidermal
growth <0.01% TSP
Hepatitis C and B treatment Rice,
turnip ( Brassica rapa) Human interferon-alpha
Not reported
Hepatitis C and B treatment Tobacco
Human interferon- beta <0.01%
fresh weight
Liver cirrhosis, burns, surgery Tobacco
Human serum albumin 0.02%
TSP
Blood substitute Tobacco
Human hemoglobin alpha, beta 0.05%
seed protein
Collagen Tobacco
Human homotrimeric collagen <0.01%
fresh weight
Cystic fibrosis, liver disease and hemorrhage
Rice Human alpha-1-antitrypsin
Not reported
Trypsin inhibitor for transplantation surgery
Maize Human aprotinin
Not reported
Antimicrobial Potato
Human lactoferrin 0.10%
TSP
Non-human proteins
Hypertension Tobacco,
tomato Angiotensin-converting enzyme
Not reported
HIV therapies Nicotiana
bethamiana alpha-Tricosanthin from
TMV-U1 Subgenomic coat protein 2.00%
TSP
Gaucher’s disease Tobacco
Glucocerebrosidase 1.00–10.00%
TSP
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