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Plant molecular farming - Nuclear Transformation method patents

Issued patents are differentiated from applications in that applications are italicized.

Arokiaraj, P., Cheong, K. F., Rahaman, Wan Y. W. A., Yeang, H. Y., Boffey, S. A., Jones, H., Slater, R. J., EP598589A3, pub July 19, 1995, Method for the production of proteins in plant fluids, The Rubber Research Inst of Malaysia/ Univ of Hertfordshire, also CA2103195AA.

Bascomb, N., Bossie, M., Sharjinskala, M., Hirayama, L., Hall, G., Petty, T., Golovko, A., Campo, M., WO 03012035, pub Feb 13, 2003, Commercial use of Arabidopsis for the production of human and animal therapeutic and diagnostic proteins, Icon Genetics, (Arabidopsis)

Brandle, J., Davies, P. L., Kenward, K. D., Menassa, R., Jevnikar, T., Delovitch, T., WO9967401A2, pub Dec 29, 1999, Non-food crop plant bioreactor, London Health Sciences Center., (also CA 2188220 Kenward et al.,)

Boffey, S. A., Jones, H., Slater, R. J., Arokiaraj, P., Cheong, K. F., Wan Abdul Rahaman, W. Y., Yeang, H. Y., US 5,580,768, Dec 3, 1996, Method for the production of proteins in plant fluids, The Univ of Hertfordshire/ Rubber Inst of Malaysia.

Bol, J. F., Cornelissen, B. J. C., van Kan, J. A. L., US 5,057,422, Oct 15, 1991, Recombinant DNA: transformed microorganisms, plant cells and plants: a process for introducing an inducible property in plants, and a process for producing a polypeptide or protein by means of plants or plant cells, Mogen Intl., also EP337532B1, Jan 7, 1999.

Botterman, J., Leemans, J., Krebbers, E., Vandekerckhove, J. S., CA1337048, Sept 19, 1995, Process for the production of biologically active peptide via the expression of modified storage seed protein genes in transgenic plants, PGS.

Cramer, C. L., Weissenborn, D. L., US 5,670,349, Sept 23, 1997, HMG2 promoter expression system and post-harvest production of gene products in plants and plant cell cultures, Virginia Tech Intellectual Properties, (CropTech). (Enzymes) (also CA 2168430 - unissued)

Cramer, C. L., Weissenborn, D. L., US 5,689,056, Nov 18, 1997, HMG2 promoter expression system, Virginia Tech Intellectual Properties, (CropTech).

Curtis, W., WO 0120974, Pub Mar 29, 2001, Quantitative transient protein expression in plant tissue culture, Penn State Research Foundation, (Agro in plant cell cultures)

Deckers, H. M., van Rooijen, G., Boothe, J., Goll, J., Mahmoud, S., Moloney, M. M., US 6,146,645, Nov 14, 2000, Uses of oil bodies, SemBioSys Genetics Inc., also CA 2291274

Deckers, H. M., van Rooijen, G., Boothe, J., Goll, J., Mahmoud, S., Moloney, M. M., US 6,210,742, April 3, 2001, Uses of oil bodies, SemBioSys Genetics Inc.

Deckers, H. M., van Rooijen, G., Boothe, J., Goll, J., Moloney, M. M., US 6,183,762, Feb 6, 2001, Oil body based personal care products, SemBioSys Genetics Inc., also CA 2290278

Deckers, H. M., van Rooijen, G., Boothe, J., Goll, J., Moloney, M. M., US 6,372,234, April 16, 2002, Products for topical applications comprising oil bodies, SemBioSys Genetics Inc., (also CA 2353071,and EP 1131047)

Deckers, H. M., van Rooijen, G., Boothe, J., Goll, J., Moloney, M. M., US 6,582,710, June 24, 2003, Products for topical applications comprising oil bodies, SemBioSys Genetics Inc.,

Deckers, H. M., van Rooijen, G., Boothe, J., Goll, J., Moloney, M. M., US 6,599,513, July 29, 2003, Products for topical applications comprising oil bodies, SemBioSys Genetics Inc.

Dickey, L., Gasdaska, J., Stomp, A-M., WO 0210414, pub Feb 7, 2002, Expression of biologically active polypeptides in duckweed, Biolex

During, K., WO0008142, pub Feb 17, 2000, Fibrous proteins and their production, MPB Cologne

During, K., Bulow, L., WO 0138508, pub May 31, 2001, Method for carrying out the controlled post-harvest production of proteins in host organisms, MPB Cologne


Fortin, M., US 5,723,755, Mar 3, 1998, Large scale production of human or animal proteins using plant bioreactors, McGill University., also CA 2300383

Heinz, E., Duwenig, E., Bischoff, F., Drexler, H., Scheffler, J., Lerchl, J., WO 02057464, pub July 7, 2002, Method for expression of biosynthetic genes in plant seeds using novel multiple expression constructs, BASF Plant Science

Jevnikar, A. M., Ma, S., Stiller, C. R., US 6,388,850, Jan 15, 2002, Methods and products for controlling the immune response of a mammal to glutamic acid decarboxylase, London Health Sciences

Jung, R., Gruis, D. B., US2002108149, pub Aug 8, 2002, Methods of increasing polypeptide accumulation in plants, Pioneer Hi-Bred Intl., (inhibition of protease)

Jungermann, E., Moloney, M. M., Boothe, J., CA 2353071, filed Nov 24, 1999, Oil bodies as topical delivery vehicles for active agents, SemBioSys Genetics Inc., (also EP1131047)

Kimyuk, V., Gleba, Y., Gils, M., Skulachev, M., Marillonet, S., WO 02088369, pub Nov 7, 2002, Processes and vectors for amplification or expression of nucleic acid sequences of interest in plants, Icon Genetics

Kyle, D. J., Reeb, S. E., Sicotte, V. J., US 5,711,983, Jan 27, 1998, Dinoflagellate biomass, methods for its production, and compositions containing the same, Martek Bioscience Corp, (algae)

Lee, J. M., Magnuson, N. S., An, G., Reeves, R., US 6,020,169, Feb 1, 2000, Production of secreted foreign polypeptides in plant cell culture, Washington State Univ Research Found.

Lemaux, P. G., Cho, M-J., Buchanan, R. B., US 6,642,437, Nov 4, 2003, Production of proteins in plant seeds, (barley) Univ of Calif., WO9916890A2, pub Apr 8, 1999, also CA 2305628, Buchanan et al., CA 2368854, and CA 2368744, Cho et al

Martens, G. J. M., Chaudhuri, B., Stephan, C., US 5,804,417, Sept 8, 1998, Recombinant production of proteins using 7B2 protein, Novartis, (chaperonin), also CA 2123567

May, G. D., Clendennen, S. K., US 6,284,946, Sept 4, 2001, Banana DNA associated with fruit development, Boyce Thompson Inst., (protein production during fruit ripening) also CA 2304109

Merot, B., Dieryck, W., Lenee, P., Marden, M., Gruber, V., Pagnier, R-J., Baudino, S., Poyart, C., US 6,344,600, Feb 5, 2002, Method for producing human haemoglobin proteins using plant cells, Meristem Therapeutics

Moloney, M., US 5,650,554, July 22, 1997, Oil-body proteins as carriers of high-value peptides in plants, SemBioSys Genetics Inc., also CA 2118113, Jan 8, 2002

Moloney, M. M., US 5,792,922, Aug 11, 1998, Oil-body protein cis-elements as regulatory signals, SemBioSys Genetics Inc., (also CA 2133417 )

Moloney, M. M., US 5,948,682, Sept 7, 1999, Preparation of heterologous proteins on oil bodies, SemBioSys Genetics Inc.

Moloney, M., Alcantara, J., Van Rooijen, G., CA 2286861, filed April 23, 1998, Method for cleavage of fusion proteins, SemBioSys Genetics Inc., also WO 9849326

Moloney, M. M., Boothe, J., Van Rooijen, G., US 6,509,453, Jan 21, 2003, Oil bodies and associated proteins as affinity matrices, SemBioSys Genetics Inc.

Moloney, M. M., van Rooijen, G., Boothe, J., US 5,856,452, Jan 5, 1999, Oil bodies and associated proteins as affinity matrices, SemBioSys Genetics Inc., (also CA 2275489 )

Rodriguez, R. L., US 5,693,506, Dec 2, 1997, Process for protein production in plants, Univ of Calif.
Also CA 2176834

Rodriguez, R. L., CA 2296008, filed June 25, 1998, Rice beta-glucanase enzymes and genes, Univ of California

Rodriguez, R. L., US 5,888,789, Mar 30, 1999, Process for protein production in plants, Univ of Calif.

Rodriguez, R. L., US 5,889,189, Mar 30, 1999, Process for protein production in plants, Univ of Calif.

Rodriguez, R. L., US 5,994,628, Nov 30, 1999, Process for protein production in plants, Univ of Calif.

Rodriguez, R. L., Huang, N., US 6,284,956, Sept 4, 2001, Plant selectable marker and plant transformation method, Applied Phytologics, (rice)


Rogers, J. C., US 5,677,474, Oct 14, 1997, Producing commercially valuable polypeptides with genetically transformed endosperm tissue, Washington Univ.

Satoh, S., Masuda, S., US 6,388,068, May 14, 2002, Method for producing foreign polypeptide in plant intercellular fluid, Noda Institute for Scientific Research, (secretion into xylem)

Sijmons, P. C., Hoekema, A., Dekker, B. M. M., Schrammeijer, B., Verwoerd, T. C., Van Den Elzen, P. J. M., US 5,650,307, July 22, 1997, Production of heterologous proteins in plants and plant cells, Mogen Intl.

Sijmons, P. C., Hoekema, A., Dekker, B. M. M., Schrammeijer, B., Verwoerd, T. C., Van Den Elzen, P. J. M., US 5,716,802, Feb 10, 1998, Production of heterologous proteins in plants and plant cells, Mogen Intl.

Sijmons, P. C., Hoekema, A., Dekker, B. M. M., Schrammeijer, B., Verwoerd, T. C., Van Den Elzen, P. J. M., US 5,763,748, June 9, 1998, Production of heterologous proteins in plants and plant cells, Mogen Intl.

Stomp, A-M., Rajbhandari, N., US 6,040,498, Mar 21, 2000, Genetically engineered duckweed, NC State Univ., also CA 2288895

Sutliff, T. D., Rodriguez, R. L., US 6,066,781, May 23, 2000, Production of mature proteins in plants, Applied Phytologics, (rice), also CA 2280894

Thornburg, R., US 5,939,288, Aug 17, 1999, Plant secretory signal peptides and nectarins, Iowa State Univ. (secretion in nectar)

Vandekerckhove, J. S., Krebbers, E., Botterman, J., Leemans, J., US 5,487,991, Jan 30, 1996, Process for the production of biologically active peptide via the expression of modified storage seed protein genes in transgenic plants, Plant Genetic Systems Inc., (also CA 1337048 - Sept 19, 1995)

van Ooijen, A. J. J., Rietveld, K., Hoekema, A., Pen, J., Sijmons, P. C., Verwoerd, T. C., Quax, W. J., US 5,543,576, Aug 6, 1996, Production of enzymes in seeds and their use, Mogen Intl.

van Ooijen, A. J. J., Rietveld, K., Hoekema, A., Pen, J., Sijmons, P. C., Verwoerd, T. C., Quax, W. J., US 5,714,474, Feb 3, 1998, Production of enzymes in seeds and their use, Mogen Intl.

Van Rooijen, G., Moloney, M. M., Deckers, H. M., Boothe, J., Goll, J., CA 2290278, filed Nov 24, 1999, Oil body based personal care products, SemBioSys Genetics Inc

Vezina, L-P., D=Aoust, M-A., US 6,420,548, Jul 16, 2002, Method for regulating transcription of foreign genes, Medicago, (N induction - alfalfa), also CA 2385347

Vezina, L-P., D=Aoust, M-A., CA 2385348, filed Oct 2, 2000, Promoter for regulating expression of foreign genes, Medicago, (light regulated)

Vezina, L-P., Laberge, S., Bazin, R., Khoudi, H., Lemieux, R., Allard, G., US 5,990,385, Nov 23, 1999, Protein production in transgenic alfalfa plants, AAFC. (Medicago), (also CA 2220563)

Yu, S-M., Liu, L-F., US 5,460,952, Oct 24, 1995, Gene expression system comprising the promoter region of the alpha amylase genes, National Science Council of ROC, (secretion system)

Yu, S-M., Liu, L-F., Chan, M-T., US 6,288,302, Sept 11, 2001, Application of alpha amylase gene promoter and a signal sequence in the production of recombinant proteins in transgenic plants and transgenic plant seeds, National Science Council, (inducible system)

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