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Molecular farming / pharming / biopharming patents for protein production in plants.

Issued patents are differentiated from applications in that applications are italicized.

Altosaar, I., Sardana, R., Tackaberry, E., Dudani, A. and Ganz, P. US 7,214,862 Production of Human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) in Plants. Issued May 8, 2007. Filing Date Nov. 26, 2003. Also filed in Canada CA 2,410,702.

Anderson, D. B., Gao, J., Dai, Z., Hooker, B., WO 0208382, pub Jan 31, 2002, Controlled environment agriculture bioreactor for heterologous protein production, Battelle Memorial Inst

Austin-Philips, S., Burgess, R. R., German, T. L., Ziegelhoffer, T., US 5,981,835, Nov 9, 1999, Transgenic plants as an alternative source of lignocellulosic-degrading enzymes, Wisconsin Alumni Research Found.

Baszczynski, C., Czapla, T., Hood, E., Meyer, T. E., Peterson, D., Rao, A. G., Register, J. C. III., Witcher, D., Howard, J., US 5,824,870, Oct 20, 1998, Commercial production of aprotinin in plants, Prodigene Inc., also WO9717453A1.

Baszczynski, C., Hood, E., Maddock, S., Meyer, T. E., Register, J. C., III., Witcher, D., Howard, J. A., US 5,767,379, June 16, 1998, Commercial production of avidin in plants, Prodigene Inc., also WO9717455A2 and, CA2232736AA.

Boothe, J., Shen, Y., Keon, R. G., Van Rooijen, G., WO 0114571, pub Mar 1, 2001, Commercial production of chymosin in plants, SemBioSys Genetics Inc.

Bruce, W. B., Hood, E., Peterson, D. J., Register, J. C., III., Witcher, D., Howard, J. A., US 5,804,694, Sept 8, 1998, Commercial production of B-glucuronidase in plants, Prodigene Inc.

Byun, K-H., Hong, J-B., Kwon, S-Y., Lee, C-E., Yang, Y., KR9607190, pub May 29, 1996, Human interlukin-6 producing tobacco, Korea Inst of Science and technology, (interleukin)

Cheng, K-J., Selinger, L. B., Liu, J-H., Hu, Y., Forsberg, C. W., Moloney, M. M., US 5,948,667, Sept 7, 1999, Xylanase obtained from an anaerobic fungus, AAFC, (xylanase expression in association with Brassica oil-bodies)

Cheng, K-J., Selinger, L. B., Liu, J-H., Hu, Y., Forsberg, C. W., Moloney, M. M., US 6,137,032, Oct 24, 2000, Xylanase obtained from an anaerobic fungus, AAFC, (xylanase expression in association with Brassica oil-bodies)

Cho, M-J., Buchanan, R. B., Lemaux, P. G., Caillau, M., Del Val, G., CA 2368854, filed Mar 31, 2000, Barley gene for thioredoxin and NADP-thioredoxin reductase, Univ of California

Cho, M-J., Buchanan, R. B., Marx, C., Lemaux, P. G., Wong, J., CA 2368744, filed Mar 29, 2000, Value-added traits in grain and seed transformed with thioredoxin, Univ of California, (thioredoxin production)

Cho, M-J., del Val, G., Caillan, M., Lemaux, P. G., Buchanan, R. B., US 6,380,372, April 30, 2002, Barley gene for thioredoxin and NADP-thioredoxin reductase, Univ of California, (thioredoxin)

Cuperus, R. A., Herweijer, M. A., Van Ooilen, A. J. J., Van Schouwen, D. J., US 5,872,091, Feb 16, 1999, Cleaning compositions containing plant cell wall degrading enzymes and their use in cleaning methods, Genencor Intl. (Cellulose degrading enzymes)

Dorlhac de Bourne, F., Faye, L., Van Oort, E., Van Ree, R., Bonneau, C., Gomord, V., FR2809413, pub Nov 30, 2001, Production of recombinant allergens in plants, D. Exp Ind. Des Tabacs et Allum

Grabau, E. A., Hegeman, C., US 6,303,766, Oct 16, 2001, Soybean phytase and nucleic acid encoding the same, Virginia Tech, ( phytase production in soybean seed)

Gruber, V., Bournat, P., Merot, B., WO 9817807, pub April 30, 1998, Pancreatic lipases and/or recombinant colipases and derived polypeptides produced by plants, methods for obtaining them and use thereof, Biocem, (lipase), also CA2269025

Gruber, V., Exposito, J-Y., Ruggiero, F., Compte, J., Garrone, R., Merot, B., Bournat, P., US 6,617,431, Sept 9, 2003 , Recombinant collagen and derived proteins produced by plants, methods for obtaining them and uses, Meristem Therapeutics (collagen), WO 9827202, pub June 25, 1998

Han, M-H, Na, D-S, Hong, J-B., Jo, H-S, Lee, H-J., KR9309562, pub Oct 7, 1993, Plant for producing IL-2, Korea Inst of Science and Technology, (Cytokine)

Hon, C. B., Ri, D. S., Ri, H. J., Kimu, S. C., Riu, J. R., Jiyun, H., JP 5041990, pub Feb 23, 1993, Tobacco for producing human insulin protein and its production, Korea Inst of Science and Technology, (insulin)

Howard, J. A., Baszczynski, C., Czapla, T., Hood, E., Meyer, T. E., Peterson, D., Rao, A. G., Register, J. C. III., Withcer, D., EP859852A1, pub Aug 26, 1998, Commercial production of aprotinin in plants, Prodigene Inc.

Howard, J. A., Baszczynski, C., Hood, E., Maddock, S., Meyer, T. E., Register, J. C. III., Witcher, D., EP862641A2, pub Sept 9, 1998, Commercial production of avidin in plants, Prodigene Inc.

Howard, J. , Bruce, W., Hood, E., Peterson, D. J., Witcher, D., WO9717454A3, pub Dec 24, 1997, Commercial production of beta-glucuronidase in plants, Prodigene Inc.

Howard, J. A., Hood, E., US 6,087,558, July 11, 2000, Commercial production of proteases in plants, Prodigene Inc., (protease)


Jilka, J. M., WO 9953037, pub Oct 21, 1999, Optimized nucleotide sequence encoding organophosphorus hydrolase and methods of use for same, Prodigene, (detoxification of organophosphorous neurotoxins)

Legrand, D., Salmon, V., Spik, G., Gruber, V., Bournat, P., Merot, B., WO 9850543, Nov 12, 1998, Recombinant lactoferrin, methods of production from plants and uses, Biocem

Legrand, D., Salmon, V., Spik, G., Gruber, V., Bournat, P., Merot, B., US 6,569,831, May 27, 2003, Recombinant lactoferrin, methods of production from plants and uses, Meristem Therapeutics

Lenee, P., Gruber, V., Baudino, S., Merot, B., Benicourt, C., Cudrey, C., WO 9633277, pub Oct 24, 1996, Recombinant preduodenal lipases and polypeptide derivatives produced by plants, processes for obtaining them and their uses, Meristem Therapeutics, (lipase) also CA 2218418

Liu, L-F., Yu, S-M., Cheng, K-J., Shaw, J-F., CA 2309342, filed June 14, 2000, Protein production in transgenic plant seeds, Academia Sinica, (hydrolytic enzymes)

Loike, J. D., Hickman, S., Holzer, D., US 5,855,881, Jan 5, 1999, Mammalian alcohol dehydrogenase and aldehyde dehydrogenase production in plants, (pills for reduction of intoxication)

Moloney, M. M., Habibi, H. R., US 6,288,304, Sept 11, 2001, Expression of somatotropin in plant seeds, SemBioSys Genetics Inc.

Mor, T. S., Soreq, H., Arntzen, C. J., Mason, H. S., US 20020162140, pub Oct 31, 2002, Expression of recombinant human acetylcholinesterase in transgenic plants, Univ of Arizona?

Oishi, K. K., Zhou, D-F., WO 0000624, pub Jan 6, 2000, Production of urokinase in plant-based expression systems, CropTech Dev Corp

Olagnier, B., Merot, B., Thiesen, M., Bournat, P., Gruber, V., EP 1051503, pub Aug 6, 1999, Method for producing, by plant cells, "-1-antitrypsin and its alleles, and products containing the resulting "-1-antitrypsin, Groupe Limagrain Holding, (antitrypsin)

Radin, D. N., Cramer, C. L., Oishi, K. K., Weissenborn, D. L., US 5,929,304, July 27, 1999, Production of lysosomal enzymes in plant-based expression systems, CropTech Development Corp.

Rao, A. G., Czapla, T., Baszyczynski, C., Register, J. C. III., Witcher, D., Howard, J. A.,
Peterson, D., Meyer, T. E., Hood, E., CA 2233538AA, pub May 15, 1997, Commercial production of aprotinin in plants, Prodigene Inc.

Ruggiero, F., Perret, S., WO 0177422, pub Oct 12, 2001, Method for the manufacture of recombinant unhydroxylated collagen polypeptide fibres obtained thereby, Meristem Therapeutics, (collagen), also CA 2405250

Scheller, J., Conrad, U., Grosse, F., Guehrs, K-H., WO 0194393, pub Dec 13, 2001, Synthetic spider silk proteins and the expression thereof in transgenic plants, IPK Inst fur Pflanzengenetik und Kulturpflanzenforschung, (spider silk)

Sutliff, T. D., Rodriguez, R. L., US 6,127,145, Oct 3, 2000, Production of alpha 1-antitrypsin in plants, Applied Phytologics, (rice)

van Ooijen, A. J. J., Rietveld, K., Hoekema, A., Pen, J., Sijmons, P. C., Verwoerd, T. C., US 5,593,963, Jan 14, 1997, Expression of phytase in plants, Mogen Intl.

van Ooijen, A. J. J., Rietveld, K., Hoekema, A., Pen, J., Sijmons, P. C., Verwoerd, T. C., US 5,770,413, June 23, 1998, Expression of phytase in plants, Mogen Intl.

van Ooijen, A. J. J., Rietveld, K., Hoekema, A., Pen, J., Sijmons, P. C., Verwoerd, T. C., US 6,022,846, Feb 8, 2000, Expression of phytase in plants, Mogen Intl.

Van Rooijen, G., Keon, R. G., Boothe, J., Shen, V., WO 0114571, pub Mar 1, 2001, Commercial production of chymosin in plants, SemBioSys Genetics, (chymosin)

Warren, G. J., Mueller, G. M., US 5,118,792, June 2, 1992, Ice crystal growth suppression polypeptides and method of making, DNA Plant Technology Corp, (antifreeze proteins)

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